THE DEFINITIVE GUIDE TO HAASS

The Definitive Guide to haass

The Definitive Guide to haass

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We are using interdisciplinary approaches ranging from biophysics, biochemistry and cellular and molecular biology to in vivo models and life imaging.

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We work on the molecular and cellular mechanisms of neurodegeneration with a strong focus on Alzheimer’s disease and related disorders. We are searching for therapeutic targets within the amyloid cascade. Secretases, amyloid metabolism and microglial function are within the focus of our research.

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Chris­t­ian Haass, Profes­sor of Metabolic Biochem­istry at LMU Munich and spokesper­son for the DZNE Munich, is known for his ground­break­ing research rein Alzheimer's disease. His work focuses on the molec­u­lar and cellu­lar mecha­nisms of this disease rein order to gain funda­men­tal insights into its devel­op­ment.

81377  München christian.haass(at)dzne.de +49 89 4400-46549 Areas of investigation/research focus Prof. Haass started to work on Alzheimer's disease (AD) in 1990 at a time, when very little was known about the cellular mechanisms involved.  Based on the pathology, which shows invariably the accumulation and deposition of Amyloid ß-peptide (Aß), he focused his work on überprüfe hier the generation and metabolism of Aß.  Christian Haass hypothesized against the widely accepted general opinion hinein this field that Aß may be produced from its precursor hinein a physiologically häufig pathway and not necessarily rein a pathological process.  Indeed he found by using very simple tissue culture systems that Aß is produced and liberated under physiological conditions.  This pivotal finding welches a major breakthrough for the entire field, since it allowed elucidating the molecular principles behind Aß generation as well as the identification of the enzymes (the so-called secretases) involved rein generation and liberation of the peptide and finally the development of selective inhibitors to therapeutically lower Aß production rein patients.

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Leichte vierrädrige Straßen-Quads mit einer Nenndauerleistung/Nutzleistung von nicht eine größere anzahl wie 4 kW außerdem vierrädrige Leichtkraftfahrzeuge mit einer Nenndauerleistung/Nutzleistung von nicht mehr denn 6 kW, jeweilig mit nicht mehr denn alle beide Sitzplätzen, einer durch die Bauart bestimmten Höchstgeschwindigkeit von nicht mehr denn 45 stundenkilometer, einer maximalen Leermasse von 425 kg außerdem einem Fremdzündungsmotor mit einem Hubraum von nicht mehr denn 50 cm³ oder einem Selbstzündungsmotor mit einem Hubraum von nicht eine größere anzahl wie 500 cm³ oder einer anderen Antriebsform.

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